Mechanism of Action
Dactinomycin for injection is a cytotoxic actinomycin that binds DNA and inhibits RNA synthesis. The cytotoxic activity of dactinomycin has been demonstrated in animal models of different human cancers.

Pharmacodynamics
Dactinomycin exposure-response relationships and the time course of pharmacodynamics response are unknown.

Pharmacokinetics
The distribution and excretion of radiolabeled dactinomycin ( 3H actinomycin D) were assessed in three adult patients with malignant melanoma.

Drug Interaction Studies
Published in vitro studies report that dactinomycin may be a substrate of the P-glycoprotein and OATP1B3 transporter systems.

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